A leading voice in Black speculative fiction for more than 20 years, Due has won an American Book Award, an NAACP Image Award, and a British Fantasy Award, and her writing has been included in best-of-the-year anthologies. Her books include The Reformatory (winner of a Los Angeles Times Book Prize, Chautauqua Prize, Bram Stoker Award, Shirley Jackson Award, World Fantasy Award, and a New York Times Notable Book), The Wishing Pool and Other Stories, Ghost Summer: Stories, My Soul to Keep, and The Good House. She and her late mother, civil rights activist Patricia Stephens Due, co-authored Freedom in the Family: A Mother-Daughter Memoir of the Fight for Civil Rights.

She was an executive producer on Shudder's groundbreaking documentary Horror Noire: A History of Black Horror. She and her husband/collaborator, Steven Barnes, recently co-directed a short film horror film, "The Keeper." They also wrote "A Small Town" for Season 2 of Jordan Peele’s "The Twilight Zone," and two segments of Shudder’s anthology film Horror Noire.